| Title | [Clinical Effects of Hange-shashin-to on Combination Therapy of S-1/Irinotecan against the for Patients with Metastatic Gastric and Colorectal Cancer.] | | Author(s) | Hibi S, Ina K, Furuta R, Kataoka T, Kojima S, Kawai M | | Institution | Dept. of Hospital Pharmacy, Nagoya Memorial Hospital. | | Source | Gan To Kagaku Ryoho 2009 Sep; 36(9):1485-8. | | Abstract | From July, 2007 to June, 2008, we prospectively investigated the influence of Hange-shashin-to on the therapeutic and adverse effects of chemotherapy and the changes in quality of life(QOL)scores of the patients with metastatic gastric and colorectal cancer. Twenty patients receiving S-1/Irinotecan(CPT-11)therapy were randomly allocated into group A(with Hange-shashin-to)and B(without Hange-shashin-to). While the anti-tumor effects did not differ significantly between these two groups, severe side effects of more than grade 3 occurred less frequently in group A. Our results suggested that the decrease in QOL scores on day 15 might be alleviated in group A, compared to group B. Therefore, Hange-shashin-to can be one of the useful supportive medicines in the combination therapy of S-1/CPT- 11. | | Language | jpn | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19755817 |
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